College of Biological Sciences Events & Seminars
These seminar/event announcement pages are made available as a service of the College of Biological Sciences. The information contained in an announcement is entered by the seminar/event sponsor, who is responsible for its accuracy. For further information about a seminar/event, please contact the sponsor. You can search for a specific event on the quick search page.
Today's Seminars/Events
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8825. Nov 9, 2009 (Mon)
Speaker: Betty A. Diamond
Affiliation: Feinstein Institute for Medical Research
Title: Autoantibodies and the Brain: Lessons from lupus
Where: M.I.N.D. Institute - 2825 50th Street, Sacramento - Room 1115
When: 4:30 p.m.
Sponsored by: UC Davis M.I.N.D. Institute
Contact: Kathy Keihl
Abstract: Systemic lupus erythematosus (SLE) is a disease characterized by the production of multiple autoantibodies, most notably antibodies to double stranded DNA. A subset of these anti-DNA antibodies cross-reacts with the NR2A and NR2B subunits of the NMDA receptor. This receptor is the primary molecular mechanism for controlling synaptic plasticity and memory function. These antibodies are present in serum of approximately 50% of patients. They can be found in cerebrospinal fluid of patients with neuropsychiatric lupus, and their titers correlate with symptomatology. They can also be found in brain tissue. In vivo in mice, they mediate memory loss if they access the hippocampus or impaired fear conditioning if they access the amygdala. These antibodies modulate excitatory post synaptic potentials at low concentration and induce mitochondrial transition permeability and apoptosis at high concentration. When these antibodies are present in serum of pregnant mice, they alter fetal brain development in a dose dependent fashion and can lead to permanent but isolated cognitive impairments.
Dr. Diamond will present information from studies that show that: 1) anti-brain antibodies may be responsible for multiple instances of altered cognition and behavior in adults, and altered brain development in fetuses, and 2) such antibodies may arise in susceptible individuals in response to microbial challenge. She will also discuss studies of anti-pneumococcal antibodies that support this hypothesis.
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8868. Nov 9, 2009 (Mon)
Speaker: Tao Sang
Affiliation: Dept. Plant Biology - U Michigan
Title: What I have learned from studying rice domestication
Where: PES 2005
When: 4:10pm
Sponsored by: Genetics Graduate Group
Contact: Ellen Picht
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8821. Nov 12, 2009 (Thu)
Speaker: Craig Stark
Affiliation: Center for the Neurobiology of Learning and Memory, UC Irvine
Title: Pattern Separation and the Aging Hippocampus
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8833. Nov 12, 2009 (Thu)
Speaker: Dr. Gerhard A. Coetzee
Affiliation: USC, Keck School of Medicine
Title: 8q24 and cancer risk
Where: UC Davis Cancer Center auditorium, 4501 X St., Sacramento
When: 9:00 am
Sponsored by: UC Davis Cancer Center Basic Science
Contact: Fran Richardson
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8877. Nov 12, 2009 (Thu)
Speaker: Karlene Cimprich
Affiliation: Stanford School of Medicine
Title: "Mechanisms for maintaining genome stability at the replication fork and beyond"
Where: 1022 Life Sciences
When: 4:10 p.m.
Sponsored by: Sponsored by: The College of Biological Sciences, Graduate Groups in Biochemistry & Molecular Biology and Cell & Developmental Biology, Section of Microbiology, Section of Molecular and Cellular Biology, Departments of Biological Chemistry and Cell Biology & Human Anatomy, the Molecular & Cellular Biology Training Grant (NIH), and the Howard Hughes Medical Institute.
Contact:
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8860. Nov 13, 2009 (Fri)
Speaker: Steve Doberstein, PhD
Affiliation: Xoma
Title: Engineering & Development of XOMA 052, a novel anti-IL-1b Antibody
Where: 1022 LSA
When: 11:00 am
Sponsored by: Biotech Program
Contact: Marianne Hunter
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8887. Nov 13, 2009 (Fri)
Speaker: Jamie Cate
Affiliation: University of California, Berkeley
Title: New Structures of the Universal Translator, the Ribosome
Where: 241 Hunt Hall
When: 2:00pm-3:00pm
Sponsored by: Biophysics Graduate Group
Contact: Ellen Picht
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8900. Nov 13, 2009 (Fri)
Speaker: David B. Weiner, Ph.D.
Affiliation: Dept. of Pathology & Laboratory Medicine; Chair, Gene Therapy & Vaccine Program, CAMB, University of Pennsylvania
Title: Directing and Improving Immune Responses Induced by DNA Vaccines in vivo
Where: Auditorium Room 1005 Genome Biomedical Science Facility
When: 12:10 pm - 1:00 pm
Sponsored by: School of Medicine, Med Microbiology & Immunology "Emerging Challenges in Microbiology & Immunology"
Contact: Sandra Vaden
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8836. Nov 16, 2009 (Mon)
Speaker: Karen Zito
Affiliation: Department of Neurobiology, Physiology, and Behavior, University of California, Davis
Title: Development and plasticity of spine synapses
Where: 1022 Life sciences
When: 12 pm noon
Sponsored by: Department of Neurobiology, Physiology, and Behavior
Contact: Dave Furlow
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8869. Nov 16, 2009 (Mon)
Speaker: Peter Morrell
Affiliation: Dept. of Agronomy and Plant Genetics - U Minnesota
Title: Population structure in wild barley: implications for barley domestication
Where: PES 2005
When: 4:10pm
Sponsored by: Genetics Graduate Group
Contact: Ellen Picht
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8898. Nov 18, 2009 (Wed)
Speaker: Lillian Fritz-Laylin
Affiliation: UC Berkeley
Title: How does Naegleria make an entire microtubule cytoskeleton in 75 minutes?
Where: 1022 Life Sciences
When: 4:10 pm
Sponsored by: Microbiology 291 Seminar Series
Contact: Sharon Boylan
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8879. Nov 19, 2009 (Thu)
Speaker: Dieter Söll
Affiliation: Yale University
Title: "The genetic code revisited - Four decades after Francis Crick"
Where: 1022 Life Sciences
When: 4:10 p.m.
Sponsored by: Sponsored by: The College of Biological Sciences, Graduate Groups in Biochemistry & Molecular Biology and Cell & Developmental Biology, Section of Microbiology, Section of Molecular and Cellular Biology, Departments of Biological Chemistry and Cell Biology & Human Anatomy, the Molecular & Cellular Biology Training Grant (NIH), and the Howard Hughes Medical Institute.
Contact:
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8861. Nov 20, 2009 (Fri)
Speaker: Jennifer Ong, PhD
Affiliation: New England Biolabs, Inc.
Title: "In vitro selection: creating new tools for molecular biology"
Where: 1022 LSA
When: 11:00 am
Sponsored by: Biotech Program
Contact: Marianne Hunter
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8889. Nov 20, 2009 (Fri)
Speaker: Chris Berger
Affiliation: University of Vermont
Title: TBA
Where: 241 Hunt Hall
When: 2:00pm-3:00pm
Sponsored by: Biophysics Graduate Group
Contact: Ellen Picht
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8902. Nov 20, 2009 (Fri)
Speaker: Edward Miao, MD, PhD
Affiliation: Institute for Systems Biology, Seattle, WA
Title: Innate Immune Detection of Bacterial Virulence Factors through Caspase 1
Where: Auditorium Room 1005 Genome Biomedical Sciences Facility
When: 12:10 pm - 1:00 pm
Sponsored by: School of Medicine, Med Microbiology & Immunology "Emerging Challenges in Microbiology & Immunology"
Contact: Sandra Vaden
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8904. Nov 20, 2009 (Fri)
Speaker: Dr. Maurice Moloney
Affiliation: Founder & Chief Scientific Officer, SemBioSys
Title: "From construct to clinic: Plant-made pharmaceuticals and drug development using green technology "
Where: 1002 Giedt Hall
When: 4:10 PM
Sponsored by: The UC Davis NSF CREATE-IGERT program, Co-Sponsored by the storer Endowment in Life Sciences
Contact:
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8870. Nov 23, 2009 (Mon)
Speaker: Roger Chetelat
Affiliation: Dept. Plant Sciences, UC Davis
Title: "Genetic diversity in wild tomatoes: how genome evolution and reproductive barriers limit its utilization"
Where: PES 2005
When: 4:10pm
Sponsored by: Genetics Graduate Group
Contact: Ellen Picht
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8837. Nov 30, 2009 (Mon)
Speaker: Craig Warden
Affiliation: Department of Neurobiology, Physiology, and Behavior, and the Rowe Genetics Program, University of California, Davis
Title: Maternal and endocrine influences on obesity
Where: 1022 Life Sciences
When: 12 pm noon
Sponsored by: Department of Neurobiology, Physiology, and Behavior
Contact: Dave Furlow
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8905. Dec 1, 2009 (Tue)
Speaker: Dr. Michael Clegg
Affiliation: UC Irvine
Major Issues in Modern Biology Lecture Seminar Series
Title: "What can Genetics Tell us about the History of Crop Domestication"
Where: AGR Room, Alumni Center
When: 4:10 pm
Sponsored by: College of Biological Sciences, Storer Life Sciences Endowment
Contact: Theresa Garcia
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8897. Dec 2, 2009 (Wed)
Speaker: Maria Marco
Affiliation: Food Science & Technology
Title: Investigating the gut ecosystem with probiotic bacteria
Where: 1022 Life Sciences
When: 4:10 pm
Sponsored by: Microbiology 291 Seminar Series
Contact: Sharon Boylan
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8878. Dec 3, 2009 (Thu)
Speaker: Steve Brill
Affiliation: Rutgers University
Title: "The Sgs1/BLM helicase in DNA repair: Insights and questions from a new functional domain and new SUMO synthetic interactor"
Where: 1022 Life Sciences
When: 4:10 p.m.
Sponsored by: Sponsored by: The College of Biological Sciences, Graduate Groups in Biochemistry & Molecular Biology and Cell & Developmental Biology, Section of Microbiology, Section of Molecular and Cellular Biology, Departments of Biological Chemistry and Cell Biology & Human Anatomy, the Molecular & Cellular Biology Training Grant (NIH), and the Howard Hughes Medical Institute.
Contact:
Abstract: The human Bloom Syndrome DNA helicase BLM and its yeast ortholog Sgs1 are large proteins that are well-known for their role in maintaining genome stability. However, the function of the N-terminal halves of these proteins is largely unknown - even though genetic analysis in yeast indicates that they are critical for Sgs1 function in-vivo. We have now performed biochemical studies on this 650 aa portion of the protein. We have identified a region that binds DNA and will describe its biochemical activities. A second approach to understanding Sgs1 function involves the study of genes required in the absence of SGS1 (1). Such synthetic-lethal screens have identified genes involved in the regulation of sumoylated proteins, such as the Slx5-Slx8 SUMO-dependent Ub ligase (2), but not the more common SUMO regulators such as the SUMO E1, E2, E3s, or Ulps. I will describe the activity of a new synthetic interactor, Wss1, involved in regulating the stability of sumoylated proteins. The results suggest that recombination-dependent DNA repair is regulated by a unique form of sumoylation.
1. Mullen, J. R., Kaliraman, V., Ibrahim, S. S., and Brill, S. J. (2001). Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase. Genetics, 157, 103-118.
2. Mullen, J. R. and Brill, S. J. (2008). Activation of the Slx5-Slx8 Ub ligase by poly-SUMO conjugates. J. Biol. Chem. 283, 19912-19921.
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8862. Dec 4, 2009 (Fri)
Speaker: Joan Greve, PhD
Affiliation: Genentech, Inc.
Title: The Magnitude & Phase of Genentech Biomedical Imaging
Where: 1022 LSA
When: 11:00 am
Sponsored by: Biotech Program
Contact: Marianne Hunter
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8888. Dec 4, 2009 (Fri)
Speaker: Bryan Krantz
Affiliation: University of California, Berkeley
Title: Structural Basis for the Pre-translocation Unfolding of Proteins by Anthrax Lethal Toxin
Where: 241 Hunt Hall
When: 2:00pm-3:00pm
Sponsored by: Biophysics Graduate Group
Contact: Ellen Picht
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8838. Dec 7, 2009 (Mon)
Speaker: Jochen Ditterich
Affiliation: Department of Neurobiology, Physiology, and Behavior, University of California, Davis
Title: Perceptual decisions between multiple alternatives and flexible decision-making
Where: 1022 Life Sciences
When: 12 pm noon
Sponsored by: Department of Neurobiology, Physiology, and Behavior
Contact: Dave Furlow
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8826. Dec 9, 2009 (Wed)
Speaker: Simon Baron-Cohen, Ph.D.
Affiliation: Cambridge University
Title: The Androgen Theory of Autism
Where: M.I.N.D. Institute - 2825 50th Street, Sacramento - Room 1115
When: 4:30 p.m.
Sponsored by: UC Davis M.I.N.D. Institute
Contact: Kathy Keihl
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8823. Dec 10, 2009 (Thu)
Speaker: Sacha Nelson
Affiliation: Department of Biology, Brandeis University
Title: Physiological Genomics of Cortical Circuits in Health and Disease
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8840. Jan 11, 2010 (Mon)
Speaker: Nikos Logothetis
Affiliation: Max Planck Institute (MPI)
Storer Lectureship in the Life Sciences
Major Issues in Modern Biology Lecture Seminar Series
Title: Electrical Microstimulation and fMRI
Where: Genome Center
When: 4:10 PM
Sponsored by: Tracy and Ruth Storer Endowment.
Contact: Theresa Garcia
Abstract: Electrical stimulation (ES) of the brain has been performed for over 100 years, and although some might say it is a crude technique for understanding the detailed mechanisms underlying different neural computations, microstimulation has made significant contributions to our knowledge in both basic and clinical research. Recently there has been resurgence in its use in the context of electrotherapy and neural prostheses. For example, ES has made it possible to at least partially restore hearing to deaf patients by delivering pulses via implanted electrodes to different regions of the cochlea. Stimulation of the basal ganglia is remarkably effective in restoring motor function to Parkinsons patients, and microstimulation of the geniculostriate visual pathway is regarded by some as a very promising (future) method for making the blind see again.
Yet, the methodology still suffers from at least two fundamental problems; (a) we do not always know exactly what is being stimulated when we pass currents through the tissue; and (b) stimulation causes activation in a large number of areas even outside the stimulation site, making it difficult to isolate and evaluate the behavioral effects of the stimulated area itself. Microstimulation during fMRI (esfMRI) could provide a unique opportunity to visualize the networks underlying electrostimulation-induced behaviors, to map neuromodulatory systems, or to develop electrotherapy and neural prosthetic devices. Last but not least, esfMRI can offer important insights into the functional neurovascular coupling. In my talk, I shall discuss findings from recent and on-going work on signal propagation during electrical stimulation. These findings not only offer some insights into functional neurovascular coupling and the interpretation of negative hemodynamic responses, but also reveal some interesting properties of the cortical microcircuits and the way they could propagate incoming population signals.
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8827. Jan 13, 2010 (Wed)
Speaker: Matthew W. State, M.D., Ph.D.
Affiliation: Yale University School of Medicine
Title: Recent Insights into the Genetics of Tourette Syndrome
Where: M.I.N.D. Institute - 2825 50th Street, Sacramento - Room 1115
When: 4:30 p.m.
Sponsored by: UC Davis M.I.N.D. Institute
Contact: Kathy Keihl
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8841. Jan 28, 2010 (Thu)
Speaker: Loren Frank
Affiliation: UC San Francisco
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: UCD Center for Neuroscience
Contact: Terry Wright
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8843. Feb 4, 2010 (Thu)
Speaker: William Mobley
Affiliation: UC San Diego
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 1100 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8828. Feb 10, 2010 (Wed)
Speaker: Marsha Mallick Seltzer, Ph.D.
Affiliation: University of Wisconsin - Madison
Title: Psychosocial and Biological Markers of Stress in the Lives of Mothers of Adolescents and Adults with ASD
Where: M.I.N.D. Institute, 2825 50th Street, Sacramento - Room 1115
When: 4:30 p.m.
Sponsored by: UC Davis M.I.N.D. Institute
Contact: Kathy Keihl
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8842. Feb 11, 2010 (Thu)
Speaker: Antonello Bonci
Affiliation: UCSF Gallo Centr
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: UCD Center for Neuroscience
Contact: Terry Wright
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8844. Feb 18, 2010 (Thu)
Speaker: Barbara Knowlton
Affiliation: UCLA
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8893. Mar 3, 2010 (Wed)
Speaker: John Lisman
Affiliation: Brandeis University
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: UCD Center for Neuroscience
Contact: Terry Wright
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8845. Mar 4, 2010 (Thu)
Speaker: Carol Barnes
Affiliation: University of Arizona
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8829. Mar 10, 2010 (Wed)
Speaker: Jacqueline N. Crawley, Ph.D.
Affiliation: National Institute of Mental Health
Title: Mouse Models of Autism to Discover Causes and Develop Treatments
Where: M.I.N.D. Institute, 2825 50th Street, Sacramento - Room 1115
When: 4:30 p.m.
Sponsored by: UC Davis M.I.N.D. Institute
Contact: Kathy Keihl
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8846. Mar 18, 2010 (Thu)
Speaker: John Huguenard
Affiliation: Stanford University
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8830. Apr 14, 2010 (Wed)
Speaker: John N. Constantino, M.D.
Affiliation: Washington University School of Medicine
Title: The Genetic Epidemiology of Autism
Where: M.I.N.D. Institute, 2825 50th Street, Sacramento - Room 1115
When: 4:30 p.m.
Sponsored by: UC Davis M.I.N.D. Institute
Contact: Kathy Keihl
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8847. Apr 15, 2010 (Thu)
Speaker: Howard Eichenbaum
Affiliation: Boston University
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8848. Apr 22, 2010 (Thu)
Speaker: Russ Poldrack
Affiliation: University of Texas, Austin
Title: "Stop it! The neural basis of response inhibition"
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8849. Apr 29, 2010 (Thu)
Speaker: Wade Regehr
Affiliation: Harvard University
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8850. May 13, 2010 (Thu)
Speaker: Jay McClelland
Affiliation: Stanford University
Title: Dynamics of reward and stimulus influences on decision making: Theory, physiology, and behavior
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8851. May 27, 2010 (Thu)
Speaker: Kalanit Grill-Spector
Affiliation: Stanford University
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8853. Jun 2, 2010 (Wed)
Speaker: Gina Turrigiano
Affiliation: Brandeis University
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright
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8852. Jun 10, 2010 (Thu)
Speaker: Dennis Dacey
Affiliation: University of Washington
Title: TBA
Where: Center for Neuroscience, 1544 Newton Ct, Research Park
When: 11:00 AM
Sponsored by: Center for Neuroscience
Contact: Terry Wright